Drug interactions
Meclofenamate + Phentolamine
Severity: Minor
Meclofenamate and Phentolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce the blood pressure lowering effect of antihypertensive drugs. The effect with phentolamine is likely modest.
What this interaction means in plain words
Meclofenamate and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis and sodium and fluid retention oppose phentolamine's effect.
What to do
Monitor blood pressure during sustained NSAID use with phentolamine and adjust the phentolamine dose if response diminishes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phentolamine
Frequently asked questions
Can I take Meclofenamate with Phentolamine?
MediHelp rates the interaction as minor. Meclofenamate and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs such as meclofenamate can reduce the blood pressure lowering effect of antihypertensive drugs. The effect with phentolamine is likely modest.
How serious is the interaction between Meclofenamate and Phentolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during sustained NSAID use with phentolamine and adjust the phentolamine dose if response diminishes.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
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