Drug interactions
Meclofenamate + Prednisone
Severity: Moderate
Meclofenamate and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and NSAID use increases the risk of peptic ulcer and gastrointestinal bleeding. The risk is greater in older patients and with long treatment or higher doses.
What this interaction means in plain words
Meclofenamate and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal damage from NSAID prostaglandin inhibition and corticosteroid effects on mucosal repair.
What to do
Use the lowest effective NSAID dose for the shortest time and add gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Meclofenamate with Prednisone?
MediHelp rates the interaction as moderate. Meclofenamate and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and NSAID use increases the risk of peptic ulcer and gastrointestinal bleeding. The risk is greater in older patients and with long treatment or higher doses.
How serious is the interaction between Meclofenamate and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and add gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report GI bleeding symptoms.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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