Drug interactions
Meclofenamate + Probenecid
Severity: Moderate
Meclofenamate and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal clearance of many NSAIDs, including meclofenamate, and may raise their levels. This could increase GI, renal and cardiovascular adverse effects.
What this interaction means in plain words
Meclofenamate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid inhibits renal tubular secretion and glucuronide conjugate clearance of meclofenamate.
What to do
Use the lowest effective meclofenamate dose and monitor for GI bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Meclofenamate with Probenecid?
MediHelp rates the interaction as moderate. Meclofenamate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal clearance of many NSAIDs, including meclofenamate, and may raise their levels. This could increase GI, renal and cardiovascular adverse effects.
How serious is the interaction between Meclofenamate and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meclofenamate dose and monitor for GI bleeding and renal function.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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