Drug interactions
Meclofenamate + Sertraline
Severity: Moderate
Meclofenamate and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID raises the risk of gastrointestinal bleeding beyond that of either drug alone. Bleeding may be serious, especially in older patients or those with prior ulcers.
What this interaction means in plain words
Meclofenamate and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
SSRIs deplete platelet serotonin and impair platelet aggregation, while NSAIDs inhibit platelet function and damage gastric mucosa, producing additive bleeding risk.
What to do
Avoid the combination where possible, or add a proton pump inhibitor for gastroprotection in at-risk patients. Monitor for melena, hematemesis and falling hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Meclofenamate with Sertraline?
MediHelp rates the interaction as moderate. Meclofenamate and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID raises the risk of gastrointestinal bleeding beyond that of either drug alone. Bleeding may be serious, especially in older patients or those with prior ulcers.
How serious is the interaction between Meclofenamate and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or add a proton pump inhibitor for gastroprotection in at-risk patients. Monitor for melena, hematemesis and falling hemoglobin.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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