Drug interactions
Meclofenamate + Ticagrelor
Severity: Moderate
Meclofenamate and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs inhibit platelet function and irritate the gastric mucosa, so with ticagrelor they raise the risk of gastrointestinal and other bleeding. Risk is greater with chronic use.
What this interaction means in plain words
Meclofenamate and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet inhibition and NSAID-related gastrointestinal mucosal injury.
What to do
Avoid long-term NSAID use where possible and use acetaminophen instead. If an NSAID is needed, consider gastroprotection with a proton pump inhibitor and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Meclofenamate with Ticagrelor?
MediHelp rates the interaction as moderate. Meclofenamate and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs inhibit platelet function and irritate the gastric mucosa, so with ticagrelor they raise the risk of gastrointestinal and other bleeding. Risk is greater with chronic use.
How serious is the interaction between Meclofenamate and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term NSAID use where possible and use acetaminophen instead. If an NSAID is needed, consider gastroprotection with a proton pump inhibitor and monitor for bleeding.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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