Drug interactions
Meclofenamate + Tolazamide
Severity: Moderate
Meclofenamate and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the hypoglycemic effect of sulfonylureas, and cases of hypoglycemia have been reported. The risk is higher with renal impairment, older age or prolonged NSAID use.
What this interaction means in plain words
Meclofenamate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible displacement from protein binding and reduced renal clearance; mechanism not fully established.
What to do
Monitor blood glucose when starting or stopping meclofenamate. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Meclofenamate with Tolazamide?
MediHelp rates the interaction as moderate. Meclofenamate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the hypoglycemic effect of sulfonylureas, and cases of hypoglycemia have been reported. The risk is higher with renal impairment, older age or prolonged NSAID use.
How serious is the interaction between Meclofenamate and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping meclofenamate. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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