Drug interactions
Meclofenamate + Vancomycin
Severity: Moderate
Meclofenamate and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce renal function and vancomycin clearance, potentially raising vancomycin levels and nephrotoxicity risk. This has been described mainly in neonates.
What this interaction means in plain words
Meclofenamate and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and vancomycin clearance.
What to do
Monitor serum creatinine and vancomycin trough levels, and consider an alternative analgesic in patients at renal risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Meclofenamate with Vancomycin?
MediHelp rates the interaction as moderate. Meclofenamate and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can reduce renal function and vancomycin clearance, potentially raising vancomycin levels and nephrotoxicity risk. This has been described mainly in neonates.
How serious is the interaction between Meclofenamate and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin trough levels, and consider an alternative analgesic in patients at renal risk.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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