Drug interactions
Meclofenamic acid + Meloxicam
Severity: Major
Meclofenamic acid and Meloxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of two NSAIDs gives no added efficacy and increases the risk of gastrointestinal bleeding, renal impairment and cardiovascular events.
What this interaction means in plain words
Meclofenamic acid and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meclofenamic acid belongs to Musculoskeletal; Meloxicam belongs to Musculoskeletal.
Why it happens
Duplicate cyclooxygenase inhibition causes additive loss of protective prostaglandins and additive platelet inhibition.
What to do
Avoid combining systemic NSAIDs; use one agent at the lowest effective dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meclofenamic acid with Meloxicam?
MediHelp rates the interaction as major. Meclofenamic acid and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of two NSAIDs gives no added efficacy and increases the risk of gastrointestinal bleeding, renal impairment and cardiovascular events.
How serious is the interaction between Meclofenamic acid and Meloxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining systemic NSAIDs; use one agent at the lowest effective dose.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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