Drug interactions
Meclofenamic acid + Ofloxacin
Severity: Moderate
Meclofenamic acid and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the central nervous system excitatory effects of fluoroquinolones and lower the seizure threshold. Seizures are uncommon but serious, and are more likely with high fluoroquinolone doses, renal impairment or underlying epilepsy.
What this interaction means in plain words
Meclofenamic acid and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonise GABA-A receptors, and some NSAIDs may potentiate this effect, increasing neuronal excitability.
What to do
Avoid the combination in patients with seizure disorders or other seizure risk factors, and keep the ofloxacin dose appropriate for renal function. Counsel patients to report tremor, confusion or seizure activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Meclofenamic acid with Ofloxacin?
MediHelp rates the interaction as moderate. Meclofenamic acid and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the central nervous system excitatory effects of fluoroquinolones and lower the seizure threshold. Seizures are uncommon but serious, and are more likely with high fluoroquinolone doses, renal impairment or underlying epilepsy.
How serious is the interaction between Meclofenamic acid and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or other seizure risk factors, and keep the ofloxacin dose appropriate for renal function. Counsel patients to report tremor, confusion or seizure activity.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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