Drug interactions
Meclofenamic acid + Paroxetine
Severity: Moderate
Meclofenamic acid and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with an SSRI such as paroxetine increases the risk of bleeding, especially upper gastrointestinal bleeding.
What this interaction means in plain words
Meclofenamic acid and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation, while NSAIDs inhibit platelet thromboxane and damage gastric mucosa, giving additive bleeding risk.
What to do
Monitor for signs of gastrointestinal bleeding and consider a proton pump inhibitor in patients at higher risk, especially the elderly. Avoid prolonged combined use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meclofenamic acid and Paroxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Paroxetine?
MediHelp rates the interaction as moderate. Meclofenamic acid and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with an SSRI such as paroxetine increases the risk of bleeding, especially upper gastrointestinal bleeding.
How serious is the interaction between Meclofenamic acid and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and consider a proton pump inhibitor in patients at higher risk, especially the elderly. Avoid prolonged combined use where possible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
