Drug interactions
Meclofenamic acid + Prednisolone
Severity: Moderate
Meclofenamic acid and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a systemic corticosteroid markedly raises the risk of peptic ulceration and gastrointestinal bleeding. The risk is greater in older patients and with prolonged use.
What this interaction means in plain words
Meclofenamic acid and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Prednisolone belongs to Endocrine.
Why it happens
NSAIDs reduce protective gastric prostaglandins while corticosteroids impair mucosal healing, giving additive GI injury.
What to do
Use the shortest duration and lowest doses, and consider gastroprotection with a proton pump inhibitor in at-risk patients. Counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Prednisolone?
MediHelp rates the interaction as moderate. Meclofenamic acid and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with a systemic corticosteroid markedly raises the risk of peptic ulceration and gastrointestinal bleeding. The risk is greater in older patients and with prolonged use.
How serious is the interaction between Meclofenamic acid and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest duration and lowest doses, and consider gastroprotection with a proton pump inhibitor in at-risk patients. Counsel patients to report black stools or abdominal pain.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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