Drug interactions
Meclofenamic acid + Spironolactone
Severity: Major
Meclofenamic acid and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of spironolactone and impair renal function. They also add to its potassium-retaining effect, so hyperkalemia and acute kidney injury may result.
What this interaction means in plain words
Meclofenamic acid and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meclofenamic acid belongs to Musculoskeletal; Spironolactone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and renin-aldosterone activity, compounding aldosterone antagonist potassium retention.
What to do
Avoid regular NSAID use where possible. If co-used, monitor serum potassium, creatinine and blood pressure, particularly after starting and in older or renally impaired patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Meclofenamic acid with Spironolactone?
MediHelp rates the interaction as major. Meclofenamic acid and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can blunt the diuretic and antihypertensive effect of spironolactone and impair renal function. They also add to its potassium-retaining effect, so hyperkalemia and acute kidney injury may result.
How serious is the interaction between Meclofenamic acid and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible. If co-used, monitor serum potassium, creatinine and blood pressure, particularly after starting and in older or renally impaired patients.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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