Drug interactions
Meclofenamic acid + Streptomycin
Severity: Moderate
Meclofenamic acid and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal prostaglandin-mediated blood flow and raise aminoglycoside concentrations, as documented mainly in preterm neonates. In adults the effect is smaller, but both drugs are nephrotoxic, so the combination can add to kidney injury risk.
What this interaction means in plain words
Meclofenamic acid and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandin synthesis lowers glomerular filtration and aminoglycoside clearance.
What to do
Monitor serum creatinine and streptomycin levels, and hydrate adequately. Avoid the combination in neonates and patients with renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meclofenamic acid and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Meclofenamic acid with Streptomycin?
MediHelp rates the interaction as moderate. Meclofenamic acid and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal prostaglandin-mediated blood flow and raise aminoglycoside concentrations, as documented mainly in preterm neonates. In adults the effect is smaller, but both drugs are nephrotoxic, so the combination can add to kidney injury risk.
How serious is the interaction between Meclofenamic acid and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and hydrate adequately. Avoid the combination in neonates and patients with renal impairment where possible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
