Drug interactions
Meclofenamic acid + Tobramycin
Severity: Moderate
Meclofenamic acid and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce aminoglycoside clearance and raise tobramycin concentrations, an effect best described in preterm infants. Both drugs can harm the kidney, so the combination increases the risk of nephrotoxicity and possibly ototoxicity.
What this interaction means in plain words
Meclofenamic acid and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and glomerular filtration, decreasing tobramycin elimination.
What to do
Monitor tobramycin trough levels and serum creatinine, and adjust the dose accordingly. Avoid the combination in neonates and in patients with renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Meclofenamic acid with Tobramycin?
MediHelp rates the interaction as moderate. Meclofenamic acid and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce aminoglycoside clearance and raise tobramycin concentrations, an effect best described in preterm infants. Both drugs can harm the kidney, so the combination increases the risk of nephrotoxicity and possibly ototoxicity.
How serious is the interaction between Meclofenamic acid and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin trough levels and serum creatinine, and adjust the dose accordingly. Avoid the combination in neonates and in patients with renal impairment where possible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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