Drug interactions
Meclofenamic acid + Valganciclovir
Severity: Minor
Meclofenamic acid and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate and ganciclovir (the active form of valganciclovir) both undergo renal tubular secretion, so they may compete for elimination. The resulting increase in exposure is probably small, though NSAIDs may also reduce renal function.
What this interaction means in plain words
Meclofenamic acid and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meclofenamic acid belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal tubular secretion via organic anion transporters, with possible NSAID-related reduction in renal perfusion.
What to do
Monitor renal function and blood counts during combined use. Adjust valganciclovir dose if creatinine clearance falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Meclofenamic acid with Valganciclovir?
MediHelp rates the interaction as minor. Meclofenamic acid and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meclofenamate and ganciclovir (the active form of valganciclovir) both undergo renal tubular secretion, so they may compete for elimination. The resulting increase in exposure is probably small, though NSAIDs may also reduce renal function.
How serious is the interaction between Meclofenamic acid and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts during combined use. Adjust valganciclovir dose if creatinine clearance falls.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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