Drug interactions
Meloxicam + Primidone
Severity: Minor
Meloxicam and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized partly to phenobarbital, which induces drug-metabolizing enzymes and may lower meloxicam exposure. Reduced symptom control is possible but the effect is usually small.
What this interaction means in plain words
Meloxicam and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meloxicam belongs to Musculoskeletal; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its metabolite phenobarbital induce hepatic CYP2C9, accelerating meloxicam metabolism.
What to do
Monitor analgesic response and adjust the meloxicam dose within labeled limits or change analgesic if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Meloxicam with Primidone?
MediHelp rates the interaction as minor. Meloxicam and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is metabolized partly to phenobarbital, which induces drug-metabolizing enzymes and may lower meloxicam exposure. Reduced symptom control is possible but the effect is usually small.
How serious is the interaction between Meloxicam and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust the meloxicam dose within labeled limits or change analgesic if efficacy is lost.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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