Drug interactions
Meloxicam + Spironolactone
Severity: Moderate
Meloxicam and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis, which can lower renal function and aldosterone-related potassium excretion, while spironolactone retains potassium. The combination raises the risk of hyperkalemia and acute kidney injury and may blunt the diuretic and antihypertensive effect.
What this interaction means in plain words
Meloxicam and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Spironolactone belongs to Cardiovascular.
Why it happens
NSAID-induced reduction in renal blood flow and renin-aldosterone suppression adds to aldosterone antagonism, impairing potassium excretion.
What to do
Monitor serum potassium and creatinine within the first weeks of combined use and periodically after. Use the lowest effective meloxicam dose and avoid in patients with renal impairment or heart failure decompensation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Meloxicam with Spironolactone?
MediHelp rates the interaction as moderate. Meloxicam and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin synthesis, which can lower renal function and aldosterone-related potassium excretion, while spironolactone retains potassium. The combination raises the risk of hyperkalemia and acute kidney injury and may blunt the diuretic and antihypertensive effect.
How serious is the interaction between Meloxicam and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine within the first weeks of combined use and periodically after. Use the lowest effective meloxicam dose and avoid in patients with renal impairment or heart failure decompensation.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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