Drug interactions
Meloxicam + Streptomycin
Severity: Moderate
Meloxicam and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin-dependent blood flow and may slow aminoglycoside clearance, raising streptomycin concentrations. This increases the risk of nephrotoxicity and ototoxicity, notably in neonates, preterm infants and renally impaired patients.
What this interaction means in plain words
Meloxicam and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal perfusion and glomerular filtration decreases aminoglycoside elimination.
What to do
Monitor serum creatinine and streptomycin levels, and adjust the dose to renal function. Avoid the combination in neonates and in patients with renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Meloxicam with Streptomycin?
MediHelp rates the interaction as moderate. Meloxicam and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs reduce renal prostaglandin-dependent blood flow and may slow aminoglycoside clearance, raising streptomycin concentrations. This increases the risk of nephrotoxicity and ototoxicity, notably in neonates, preterm infants and renally impaired patients.
How serious is the interaction between Meloxicam and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and adjust the dose to renal function. Avoid the combination in neonates and in patients with renal impairment where possible.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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