Drug interactions
Meloxicam + Tobramycin
Severity: Moderate
Meloxicam and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of tobramycin and add to renal toxicity, leading to higher aminoglycoside levels. The risk of nephrotoxicity and ototoxicity is greatest in neonates, preterm infants and renally impaired patients.
What this interaction means in plain words
Meloxicam and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal prostaglandin-mediated perfusion decreases aminoglycoside elimination.
What to do
Monitor serum creatinine and tobramycin trough levels and adjust dosing accordingly. Avoid concurrent use in neonates and in renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Meloxicam with Tobramycin?
MediHelp rates the interaction as moderate. Meloxicam and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of tobramycin and add to renal toxicity, leading to higher aminoglycoside levels. The risk of nephrotoxicity and ototoxicity is greatest in neonates, preterm infants and renally impaired patients.
How serious is the interaction between Meloxicam and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels and adjust dosing accordingly. Avoid concurrent use in neonates and in renal impairment where possible.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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