Drug interactions
Meloxicam + Triamterene
Severity: Major
Meloxicam and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise potassium and NSAIDs reduce renal perfusion, and the combination has been associated with acute kidney injury. Hyperkalemia and reduced diuretic effect may result.
What this interaction means in plain words
Meloxicam and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meloxicam belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
Prostaglandin inhibition lowers renal blood flow and potassium excretion, adding to triamterene's blockade of epithelial sodium channels.
What to do
Avoid if possible, particularly in older patients or those with renal impairment. If used, monitor potassium and renal function regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Meloxicam with Triamterene?
MediHelp rates the interaction as major. Meloxicam and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can raise potassium and NSAIDs reduce renal perfusion, and the combination has been associated with acute kidney injury. Hyperkalemia and reduced diuretic effect may result.
How serious is the interaction between Meloxicam and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, particularly in older patients or those with renal impairment. If used, monitor potassium and renal function regularly.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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