Drug interactions
Melphalan + Trastuzumab
Severity: Moderate
Melphalan and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy has been linked to more neutropenia and febrile neutropenia. With melphalan the risk of infection may be increased.
What this interaction means in plain words
Melphalan and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Melphalan belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity; trastuzumab's contribution is not fully understood.
What to do
Monitor neutrophil counts and infection signs, using dose delay or growth factor support as the protocol allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicated
- Bcg vaccine live + Melphalan Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicated
- Measles mumps and rubella vaccine live + Melphalan Contraindicated
- Measles mumps and rubella vaccine + Melphalan Contraindicated
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Melphalan with Trastuzumab?
MediHelp rates the interaction as moderate. Melphalan and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy has been linked to more neutropenia and febrile neutropenia. With melphalan the risk of infection may be increased.
How serious is the interaction between Melphalan and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and infection signs, using dose delay or growth factor support as the protocol allows.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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