Drug interactions
Memantine-donepezil + Methyclothiazide
Severity: Minor
Memantine-donepezil and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated partly by renal tubular secretion. Thiazides may reduce its clearance modestly, and thiazide-induced electrolyte disturbances may also matter in this population.
What this interaction means in plain words
Memantine-donepezil and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion, plus effects on urinary pH and electrolytes.
What to do
Monitor for memantine adverse effects such as dizziness, confusion and agitation. Check electrolytes and renal function periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Frequently asked questions
Can I take Memantine-donepezil with Methyclothiazide?
MediHelp rates the interaction as minor. Memantine-donepezil and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated partly by renal tubular secretion. Thiazides may reduce its clearance modestly, and thiazide-induced electrolyte disturbances may also matter in this population.
How serious is the interaction between Memantine-donepezil and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for memantine adverse effects such as dizziness, confusion and agitation. Check electrolytes and renal function periodically.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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