Drug interactions
Memantine-donepezil + Metronidazole
Severity: Minor
Memantine-donepezil and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may weakly inhibit CYP3A4 and raise donepezil concentrations. Effects would be mostly mild cholinergic symptoms and are uncommon.
What this interaction means in plain words
Memantine-donepezil and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine-donepezil belongs to Central Nervous System; Metronidazole belongs to Anti Parasitic.
Why it happens
Weak inhibition of CYP3A4-mediated donepezil metabolism.
What to do
No dose change; monitor for nausea, vomiting or bradycardia during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Memantine-donepezil with Metronidazole?
MediHelp rates the interaction as minor. Memantine-donepezil and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole may weakly inhibit CYP3A4 and raise donepezil concentrations. Effects would be mostly mild cholinergic symptoms and are uncommon.
How serious is the interaction between Memantine-donepezil and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change; monitor for nausea, vomiting or bradycardia during treatment.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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