Drug interactions
Memantine-donepezil + Tenofovir df
Severity: Minor
Memantine-donepezil and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated mainly by the kidney with active tubular secretion, and tenofovir may compete for renal transport. Levels of either drug could rise, particularly in patients with renal impairment, though clinical data are limited.
What this interaction means in plain words
Memantine-donepezil and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion reduces clearance of memantine.
What to do
Monitor renal function and memantine adverse effects such as dizziness and confusion, and adjust the memantine dose if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Frequently asked questions
Can I take Memantine-donepezil with Tenofovir df?
MediHelp rates the interaction as minor. Memantine-donepezil and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated mainly by the kidney with active tubular secretion, and tenofovir may compete for renal transport. Levels of either drug could rise, particularly in patients with renal impairment, though clinical data are limited.
How serious is the interaction between Memantine-donepezil and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and memantine adverse effects such as dizziness and confusion, and adjust the memantine dose if renal function declines.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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