Drug interactions
Memantine-donepezil + Trifluoperazine
Severity: Moderate
Memantine-donepezil and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is a phenothiazine that can prolong the QT interval, and donepezil may also contribute to QT prolongation and bradycardia. In addition, its anticholinergic activity may oppose donepezil's cholinergic effect.
What this interaction means in plain words
Memantine-donepezil and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation together with pharmacodynamic antagonism of cholinergic effect.
What to do
Check ECG and electrolytes at baseline and during therapy, and monitor for worsening cognition or reduced donepezil benefit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Frequently asked questions
Can I take Memantine-donepezil with Trifluoperazine?
MediHelp rates the interaction as moderate. Memantine-donepezil and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is a phenothiazine that can prolong the QT interval, and donepezil may also contribute to QT prolongation and bradycardia. In addition, its anticholinergic activity may oppose donepezil's cholinergic effect.
How serious is the interaction between Memantine-donepezil and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during therapy, and monitor for worsening cognition or reduced donepezil benefit.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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