Drug interactions
Meningococcal a c y and w-135 polysaccharide vaccine combined + Prednisone
Severity: Moderate
Meningococcal a c y and w-135 polysaccharide vaccine combined and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a non-live vaccine, so there is no infection risk, but prednisone at immunosuppressive doses may weaken the antibody response. Protection may therefore be lower than expected.
What this interaction means in plain words
Meningococcal a c y and w-135 polysaccharide vaccine combined and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid suppression of B- and T-cell function reduces antibody production after vaccination.
What to do
Vaccination does not need to be withheld; ideally vaccinate before starting prolonged steroid therapy or when the dose is lowered. Consider checking antibody response or booster dosing in patients on high-dose therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meningococcal a c y and w-135 polysaccharide vaccine combined and Prednisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Meningococcal a c y and w-135 polysaccharide vaccine combined with Prednisone?
MediHelp rates the interaction as moderate. Meningococcal a c y and w-135 polysaccharide vaccine combined and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a non-live vaccine, so there is no infection risk, but prednisone at immunosuppressive doses may weaken the antibody response. Protection may therefore be lower than expected.
How serious is the interaction between Meningococcal a c y and w-135 polysaccharide vaccine combined and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination does not need to be withheld; ideally vaccinate before starting prolonged steroid therapy or when the dose is lowered. Consider checking antibody response or booster dosing in patients on high-dose therapy.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
