Drug interactions
Meningococcal group b vaccine + Mitoxantrone
Severity: Moderate
Meningococcal group b vaccine and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitoxantrone is myelosuppressive and immunosuppressive, so antibody responses to the meningococcal B vaccine may be blunted. The patient may remain inadequately protected despite vaccination.
What this interaction means in plain words
Meningococcal group b vaccine and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mitoxantrone-induced suppression of lymphocytes and bone marrow reduces the immune response to vaccine antigens.
What to do
Where possible, give the vaccine at least a few weeks before starting mitoxantrone or between cycles when counts have recovered. Consider checking response if protection is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meningococcal group b vaccine and Mitoxantrone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mitoxantrone
Frequently asked questions
Can I take Meningococcal group b vaccine with Mitoxantrone?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitoxantrone is myelosuppressive and immunosuppressive, so antibody responses to the meningococcal B vaccine may be blunted. The patient may remain inadequately protected despite vaccination.
How serious is the interaction between Meningococcal group b vaccine and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine at least a few weeks before starting mitoxantrone or between cycles when counts have recovered. Consider checking response if protection is essential.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
