Drug interactions
Meningococcal group b vaccine + Pralatrexate
Severity: Moderate
Meningococcal group b vaccine and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pralatrexate may reduce the immune response to the inactivated meningococcal B vaccine, leaving patients with weaker protection. The vaccine itself remains safe to give.
What this interaction means in plain words
Meningococcal group b vaccine and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine-induced antibody response.
What to do
Vaccinate ideally before chemotherapy or between cycles. Consider revaccination or antibody checks if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Frequently asked questions
Can I take Meningococcal group b vaccine with Pralatrexate?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pralatrexate may reduce the immune response to the inactivated meningococcal B vaccine, leaving patients with weaker protection. The vaccine itself remains safe to give.
How serious is the interaction between Meningococcal group b vaccine and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before chemotherapy or between cycles. Consider revaccination or antibody checks if given during treatment.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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