Drug interactions
Meningococcal group b vaccine + Vinblastine
Severity: Moderate
Meningococcal group b vaccine and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Myelosuppressive chemotherapy can blunt the antibody response to inactivated vaccines such as the meningococcal B vaccine. Patients may therefore be left with inadequate protection despite vaccination.
What this interaction means in plain words
Meningococcal group b vaccine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces lymphocyte function and the immune response to vaccine antigens.
What to do
When possible, vaccinate at least two weeks before starting chemotherapy or delay until immune recovery after treatment. If given during therapy, consider checking the response or revaccinating later.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Meningococcal group b vaccine with Vinblastine?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Myelosuppressive chemotherapy can blunt the antibody response to inactivated vaccines such as the meningococcal B vaccine. Patients may therefore be left with inadequate protection despite vaccination.
How serious is the interaction between Meningococcal group b vaccine and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When possible, vaccinate at least two weeks before starting chemotherapy or delay until immune recovery after treatment. If given during therapy, consider checking the response or revaccinating later.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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