Drug interactions
Meprobamate + Metaxalone
Severity: Moderate
Meprobamate and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic, and combining it with metaxalone can increase drowsiness, dizziness and psychomotor impairment. The risk of falls and accidents is greater in older patients.
What this interaction means in plain words
Meprobamate and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from two sedating agents.
What to do
Avoid the combination where possible, or use the lowest effective doses and monitor for oversedation. Advise against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Meprobamate with Metaxalone?
MediHelp rates the interaction as moderate. Meprobamate and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic, and combining it with metaxalone can increase drowsiness, dizziness and psychomotor impairment. The risk of falls and accidents is greater in older patients.
How serious is the interaction between Meprobamate and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective doses and monitor for oversedation. Advise against driving and alcohol use.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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