Drug interactions
Meprobamate + Orphenadrin
Severity: Moderate
Meprobamate and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic and orphenadrine adds sedation and anticholinergic effects. The combination may cause marked drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Meprobamate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses, avoid driving, and avoid in older patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Meprobamate with Orphenadrin?
MediHelp rates the interaction as moderate. Meprobamate and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic and orphenadrine adds sedation and anticholinergic effects. The combination may cause marked drowsiness and impaired psychomotor performance.
How serious is the interaction between Meprobamate and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, avoid driving, and avoid in older patients where possible.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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