Drug interactions
Meprobamate + Thioridazine
Severity: Moderate
Meprobamate and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combining them can produce more drowsiness, slowed reaction time and impaired psychomotor performance than either alone. Elderly patients and those who drive or operate machinery are at particular risk.
What this interaction means in plain words
Meprobamate and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from a sedating phenothiazine and an anxiolytic sedative.
What to do
Start with the lowest effective doses and counsel the patient to avoid driving and alcohol. Reduce the dose of one agent if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Meprobamate with Thioridazine?
MediHelp rates the interaction as moderate. Meprobamate and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combining them can produce more drowsiness, slowed reaction time and impaired psychomotor performance than either alone. Elderly patients and those who drive or operate machinery are at particular risk.
How serious is the interaction between Meprobamate and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and counsel the patient to avoid driving and alcohol. Reduce the dose of one agent if excessive sedation occurs.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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