Drug interactions
Mesalamine + Methyclothiazide
Severity: Minor
Mesalamine and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics use renal anion secretion and may theoretically compete with mesalamine metabolites. No clinically relevant effect has been demonstrated.
What this interaction means in plain words
Mesalamine and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for renal tubular organic anion secretion.
What to do
No empirical change is needed. Monitor renal function periodically during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Mesalamine with Methyclothiazide?
MediHelp rates the interaction as minor. Mesalamine and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics use renal anion secretion and may theoretically compete with mesalamine metabolites. No clinically relevant effect has been demonstrated.
How serious is the interaction between Mesalamine and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical change is needed. Monitor renal function periodically during long-term combined use.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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