Drug interactions
Mesalamine + Mycophenolate
Severity: Minor
Mesalamine and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolic acid glucuronide is eliminated partly by renal tubular secretion, and other organic anions could compete for this. Mesalamine may modestly raise mycophenolate metabolite exposure, and both can affect blood counts or renal function.
What this interaction means in plain words
Mesalamine and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion of acidic metabolites; the effect is theoretical and not well characterised.
What to do
Monitor complete blood counts and renal function as already required for mycophenolate. No dose change is needed routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Mesalamine with Mycophenolate?
MediHelp rates the interaction as minor. Mesalamine and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mycophenolic acid glucuronide is eliminated partly by renal tubular secretion, and other organic anions could compete for this. Mesalamine may modestly raise mycophenolate metabolite exposure, and both can affect blood counts or renal function.
How serious is the interaction between Mesalamine and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function as already required for mycophenolate. No dose change is needed routinely.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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