Drug interactions
Mesalamine + Parecoxib
Severity: Moderate
Mesalamine and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, a COX-2 inhibitor that can reduce renal perfusion. Together with mesalamine, which can rarely cause interstitial nephritis, renal injury risk may rise.
What this interaction means in plain words
Mesalamine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from COX-2 inhibition of renal prostaglandins and mesalamine tubulointerstitial toxicity.
What to do
Monitor serum creatinine and hydration status, and use the lowest effective parecoxib dose for the shortest time. Avoid in patients with significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Mesalamine with Parecoxib?
MediHelp rates the interaction as moderate. Mesalamine and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to valdecoxib, a COX-2 inhibitor that can reduce renal perfusion. Together with mesalamine, which can rarely cause interstitial nephritis, renal injury risk may rise.
How serious is the interaction between Mesalamine and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and hydration status, and use the lowest effective parecoxib dose for the shortest time. Avoid in patients with significant renal impairment.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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