Drug interactions
Mesalamine + Salicylates
Severity: Moderate
Mesalamine and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine is itself a salicylate derivative, and combining it with other salicylates may add to renal toxicity risk. The concern is greatest with high-dose salicylates, dehydration or existing renal disease.
What this interaction means in plain words
Mesalamine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal toxicity and overlapping salicylate effects on renal prostaglandins and tubulointerstitium.
What to do
Monitor serum creatinine and urinalysis during combined use and maintain hydration. Reduce or stop the other salicylate if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Mesalamine with Salicylates?
MediHelp rates the interaction as moderate. Mesalamine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine is itself a salicylate derivative, and combining it with other salicylates may add to renal toxicity risk. The concern is greatest with high-dose salicylates, dehydration or existing renal disease.
How serious is the interaction between Mesalamine and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urinalysis during combined use and maintain hydration. Reduce or stop the other salicylate if renal function declines.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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