Drug interactions
Mestranol + Metyrapone
Severity: Minor
Mestranol and Metyrapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol, an estrogen used in oral contraceptives, raises cortisol-binding globulin and total cortisol, which can distort the metyrapone test, and a reduced response has been described.
What this interaction means in plain words
Mestranol and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogen-induced rise in cortisol-binding globulin alters cortisol measurements; the exact mechanism for reduced metyrapone response is not firmly established.
What to do
For diagnostic testing, consider stopping estrogen-containing products beforehand or interpret results accordingly. During treatment, monitor free cortisol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Mestranol with Metyrapone?
MediHelp rates the interaction as minor. Mestranol and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mestranol, an estrogen used in oral contraceptives, raises cortisol-binding globulin and total cortisol, which can distort the metyrapone test, and a reduced response has been described.
How serious is the interaction between Mestranol and Metyrapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For diagnostic testing, consider stopping estrogen-containing products beforehand or interpret results accordingly. During treatment, monitor free cortisol.
What other medicines interact with Metyrapone?
MediHelp also lists interactions of Metyrapone with, for example, Pacritinib, Budesonide, Cortisone. The full list is on the Metyrapone page.
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