Drug interactions
Mestranol + Naratriptan
Severity: Minor
Mestranol and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol is converted to ethinylestradiol, which may modestly alter naratriptan clearance, but no clinically important effect has been established.
What this interaction means in plain words
Mestranol and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible small change in naratriptan clearance; the mechanism is not well established.
What to do
No dose adjustment of naratriptan is needed. Review estrogen-containing contraception if the patient has migraine with aura.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Mestranol with Naratriptan?
MediHelp rates the interaction as minor. Mestranol and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mestranol is converted to ethinylestradiol, which may modestly alter naratriptan clearance, but no clinically important effect has been established.
How serious is the interaction between Mestranol and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment of naratriptan is needed. Review estrogen-containing contraception if the patient has migraine with aura.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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