Drug interactions
Mestranol + Nicardipine
Severity: Minor
Mestranol and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein in vitro, but mestranol, a prodrug of ethinylestradiol, is not clearly dependent on this transporter. No clinically relevant effect on estrogen exposure has been established.
What this interaction means in plain words
Mestranol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical P-glycoprotein inhibition; the clinical relevance is not established.
What to do
No adjustment is required. Monitor blood pressure, as estrogens can raise it in patients being treated for hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Mestranol with Nicardipine?
MediHelp rates the interaction as minor. Mestranol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits P-glycoprotein in vitro, but mestranol, a prodrug of ethinylestradiol, is not clearly dependent on this transporter. No clinically relevant effect on estrogen exposure has been established.
How serious is the interaction between Mestranol and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required. Monitor blood pressure, as estrogens can raise it in patients being treated for hypertension.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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