Drug interactions
Mestranol + Prednisone
Severity: Minor
Mestranol and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens raise prednisolone exposure by reducing its clearance and increasing binding proteins, which may increase corticosteroid effects. The reverse effect, prednisone lowering mestranol, is not clinically established.
What this interaction means in plain words
Mestranol and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens reduce corticosteroid clearance; prednisone has no established effect on mestranol.
What to do
No routine change needed. Monitor for enhanced corticosteroid effects when starting or stopping estrogen-containing contraceptives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Mestranol with Prednisone?
MediHelp rates the interaction as minor. Mestranol and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens raise prednisolone exposure by reducing its clearance and increasing binding proteins, which may increase corticosteroid effects. The reverse effect, prednisone lowering mestranol, is not clinically established.
How serious is the interaction between Mestranol and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Monitor for enhanced corticosteroid effects when starting or stopping estrogen-containing contraceptives.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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