Drug interactions
Mestranol + Quinidine
Severity: Minor
Mestranol and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may inhibit P-glycoprotein and slightly raise mestranol exposure, but this is of little clinical consequence. Hormonal contraceptive efficacy is not expected to be affected.
What this interaction means in plain words
Mestranol and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by quinidine increases estrogen exposure.
What to do
No action is needed beyond awareness. Monitor for estrogenic adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Mestranol with Quinidine?
MediHelp rates the interaction as minor. Mestranol and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine may inhibit P-glycoprotein and slightly raise mestranol exposure, but this is of little clinical consequence. Hormonal contraceptive efficacy is not expected to be affected.
How serious is the interaction between Mestranol and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness. Monitor for estrogenic adverse effects if symptoms arise.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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