Drug interactions
Mestranol + Verapamil
Severity: Minor
Mestranol and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase exposure to estrogens such as ethinylestradiol by inhibiting CYP3A4. Mestranol is a prodrug converted to ethinylestradiol, so the effect is likely small but could increase estrogenic adverse effects.
What this interaction means in plain words
Mestranol and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Verapamil inhibits CYP3A4 and P-glycoprotein, possibly reducing estrogen clearance.
What to do
No routine dose change is needed. Monitor for estrogenic adverse effects such as breast tenderness, nausea or breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Mestranol with Verapamil?
MediHelp rates the interaction as minor. Mestranol and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may increase exposure to estrogens such as ethinylestradiol by inhibiting CYP3A4. Mestranol is a prodrug converted to ethinylestradiol, so the effect is likely small but could increase estrogenic adverse effects.
How serious is the interaction between Mestranol and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for estrogenic adverse effects such as breast tenderness, nausea or breakthrough bleeding.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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