Drug interactions
Metaproterenol + Nadolol
Severity: Major
Metaproterenol and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol blocks beta-2 receptors and can antagonize the bronchodilator effect of metaproterenol, risking bronchospasm and loss of asthma control. Metaproterenol may in turn reduce the antihypertensive or heart rate effects of nadolol.
What this interaction means in plain words
Metaproterenol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive antagonism at beta-adrenergic receptors between a nonselective beta-blocker and a beta agonist.
What to do
Avoid nonselective beta-blockers in patients requiring beta-agonist bronchodilators; use a cardioselective agent if a beta-blocker is necessary. Monitor respiratory function and heart rate closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Metaproterenol with Nadolol?
MediHelp rates the interaction as major. Metaproterenol and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol blocks beta-2 receptors and can antagonize the bronchodilator effect of metaproterenol, risking bronchospasm and loss of asthma control. Metaproterenol may in turn reduce the antihypertensive or heart rate effects of nadolol.
How serious is the interaction between Metaproterenol and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta-blockers in patients requiring beta-agonist bronchodilators; use a cardioselective agent if a beta-blocker is necessary. Monitor respiratory function and heart rate closely.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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