Drug interactions
Metaproterenol + Tranylcypromine
Severity: Major
Metaproterenol and Tranylcypromine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine may exaggerate the cardiovascular effects of metaproterenol, with risk of tachycardia, hypertension and arrhythmias. Labeling for beta-agonists advises extreme caution with MAOIs.
What this interaction means in plain words
Metaproterenol and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition increases catecholamine availability and adrenergic responsiveness, additive to beta-agonist effects.
What to do
Prefer an alternative bronchodilator, such as an inhaled anticholinergic, in patients on an MAOI. If unavoidable, use the lowest effective dose and monitor heart rate, blood pressure and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Metaproterenol with Tranylcypromine?
MediHelp rates the interaction as major. Metaproterenol and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranylcypromine may exaggerate the cardiovascular effects of metaproterenol, with risk of tachycardia, hypertension and arrhythmias. Labeling for beta-agonists advises extreme caution with MAOIs.
How serious is the interaction between Metaproterenol and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative bronchodilator, such as an inhaled anticholinergic, in patients on an MAOI. If unavoidable, use the lowest effective dose and monitor heart rate, blood pressure and ECG.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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