Drug interactions
Metaproterenol + Ziprasidone
Severity: Moderate
Metaproterenol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol is a beta-2 agonist that can cause tachycardia, hypokalemia and tremor, while ziprasidone prolongs the QT interval. Hypokalemia and tachycardia from the agonist may increase arrhythmic risk, especially with systemic or high-dose use.
What this interaction means in plain words
Metaproterenol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist induced hypokalemia and tachycardia may add to ziprasidone QT prolongation (pharmacodynamic).
What to do
Monitor potassium and ECG in patients with cardiac risk factors or using high doses. Correct hypokalemia and use the lowest effective bronchodilator dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metaproterenol and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Metaproterenol with Ziprasidone?
MediHelp rates the interaction as moderate. Metaproterenol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol is a beta-2 agonist that can cause tachycardia, hypokalemia and tremor, while ziprasidone prolongs the QT interval. Hypokalemia and tachycardia from the agonist may increase arrhythmic risk, especially with systemic or high-dose use.
How serious is the interaction between Metaproterenol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and ECG in patients with cardiac risk factors or using high doses. Correct hypokalemia and use the lowest effective bronchodilator dose.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
