Drug interactions
Metaxalone + Methylenedioxymethamphetamine
Severity: Moderate
Metaxalone and Methylenedioxymethamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a serotonin-releasing stimulant, and metaxalone has weak serotonergic activity and can contribute to serotonin toxicity. Sedation from metaxalone may also mask the effects of MDMA, which can lead to overuse. MDMA is an illicit drug with unpredictable effects.
What this interaction means in plain words
Metaxalone and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects with opposing sedative and stimulant effects; the mechanism is not firmly established.
What to do
Advise against combining them. Monitor for agitation, hyperthermia, tremor and other signs of serotonin syndrome if exposure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Methylenedioxymethamphetamine?
MediHelp rates the interaction as moderate. Metaxalone and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a serotonin-releasing stimulant, and metaxalone has weak serotonergic activity and can contribute to serotonin toxicity. Sedation from metaxalone may also mask the effects of MDMA, which can lead to overuse. MDMA is an illicit drug with unpredictable effects.
How serious is the interaction between Metaxalone and Methylenedioxymethamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against combining them. Monitor for agitation, hyperthermia, tremor and other signs of serotonin syndrome if exposure occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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