Drug interactions
Metaxalone + Metoclopramide intranasal
Severity: Moderate
Metaxalone and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness and extrapyramidal effects, which may add to the sedative effects of metaxalone. The combined effect on alertness may impair driving and other tasks.
What this interaction means in plain words
Metaxalone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for excess sedation and movement disorders and advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Metaxalone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness and extrapyramidal effects, which may add to the sedative effects of metaxalone. The combined effect on alertness may impair driving and other tasks.
How serious is the interaction between Metaxalone and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and movement disorders and advise patients to avoid driving until the response is known.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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