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Drug interactions

Metaxalone + Motherwort

Severity: Minor

Metaxalone and Motherwort: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Motherwort has traditional sedative properties and may add to the drowsiness caused by metaxalone. Clinical data on this combination are scarce.

What this interaction means in plain words

Metaxalone and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Evidence level: Low

Why it happens

Possible additive sedation; the mechanism of motherwort is not well established.

What to do

Counsel the patient about drowsiness and caution with driving. Stop the herbal product if excessive sedation occurs.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Metaxalone with Motherwort?

MediHelp rates the interaction as minor. Metaxalone and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort has traditional sedative properties and may add to the drowsiness caused by metaxalone. Clinical data on this combination are scarce.

How serious is the interaction between Metaxalone and Motherwort?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and caution with driving. Stop the herbal product if excessive sedation occurs.

What other medicines interact with Metaxalone?

MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.

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