Drug interactions
Metaxalone + Moxonidine
Severity: Moderate
Metaxalone and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness and dry mouth, and metaxalone adds to the sedation. Dizziness and low blood pressure may increase the risk of falls.
What this interaction means in plain words
Metaxalone and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression and sympatholytic effect.
What to do
Monitor for sedation and orthostatic symptoms, especially when starting either drug. Reduce doses if the patient is oversedated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Moxonidine?
MediHelp rates the interaction as moderate. Metaxalone and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause drowsiness and dry mouth, and metaxalone adds to the sedation. Dizziness and low blood pressure may increase the risk of falls.
How serious is the interaction between Metaxalone and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, especially when starting either drug. Reduce doses if the patient is oversedated.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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