Drug interactions
Metaxalone + Nefazodone
Severity: Moderate
Metaxalone and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may raise metaxalone exposure, increasing sedation and adverse effects. Both drugs also have serotonergic activity, so serotonin toxicity is a theoretical concern.
What this interaction means in plain words
Metaxalone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, reducing metaxalone clearance, with possible additive serotonergic and sedative effects.
What to do
Start with a lower metaxalone dose and monitor for sedation, dizziness and signs of serotonin syndrome. Reduce or stop the metaxalone if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Nefazodone?
MediHelp rates the interaction as moderate. Metaxalone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may raise metaxalone exposure, increasing sedation and adverse effects. Both drugs also have serotonergic activity, so serotonin toxicity is a theoretical concern.
How serious is the interaction between Metaxalone and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower metaxalone dose and monitor for sedation, dizziness and signs of serotonin syndrome. Reduce or stop the metaxalone if toxicity appears.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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